BIOSEEKI INTELLIGENCE · DAILY SIGNAL
聚焦精准医疗、肿瘤生物学、AI 药物发现、组学、结构生物学与 AI for Science。每一天的入选结果独立归档，论文发表日期和快讯入选日期分开记录。
Europe PMC · 论文发布 2026-10-02
Artificial intelligence is changing how cancer biology is read, searched, modeled, and turned into hypotheses. But scientific AI does not meet biology directly. Much of what it learns has already passed through English, abstracts, pathway l…
Europe PMC · 论文发布 2026-09-30
Abstract Background Generative artificial intelligence (AI) and large language model (LLM)–based simulated patients are being evaluated for problem-based learning and case-based learning in undergraduate medical education, but delivery form…
Europe PMC · 论文发布 2026-09-30
Artificial intelligence (AI), particularly large language models (LLMs), offers clinical hypnotists a powerful and immediately accessible set of tools for enhancing practice. Despite growing interest at the intersection of AI and mental hea…
Europe PMC · 论文发布 2026-09-28
Artificial intelligence (AI) is rapidly transforming healthcare through advances in machine learning, predictive analytics, and large language models. These technologies offer substantial opportunities to improve diagnostic support, informa…
Europe PMC · 论文发布 2026-10-01
Objective To investigate whether the Sydney Triage to Admission Risk Tool with Artificial Intelligence (START-AI) model could be used to predict specific inpatient admitting teams based on clinical notes. Methods This was a pre-trained lang…
Europe PMC · 论文发布 2026-10-01
Large language models (LLMs) represent a type of generative artificial intelligence (GenAI) that generate and interpret text, with some LLMs able to process multimodal content (e.g., images, audio, video), and can be deployed as part of age…
Europe PMC · 论文发布 2026-09-25
Accurate modelling of biomolecular interactions is fundamental to drug discovery, yet current artificial intelligence (AI) workflows remain fragmented across structure prediction, affinity estimation, molecular design, and experimental deci…
Europe PMC · 论文发布 2026-09-23
Progress in artificial intelligence has produced a rapidly growing ecosystem of methods for de novo protein design. With access to many specialized and often complementary tools, how does one use them effectively, especially with a finite c…
Europe PMC · 论文发布 2026-09-23
Young adult cancer survivors (ages 18-39) often experience persistent treatment-related symptoms that negatively affect daily functioning, psychosocial well-being, and quality of life, yet report unmet educational needs for symptom manageme…
Europe PMC · 论文发布 2026-09-21
Artificial Intelligence (AI) in dermatology is a rapidly evolving field, offering promising advancements in the diagnosis and management of skin cancers. As global skin cancer incidence rises, tools like machine-learning based systems and l…
Europe PMC · 论文发布 2026-09-20
Generative artificial intelligence (AI) has emerged as a potential source of formative feedback for student writing. However, relatively little is known about how AI-generated feedback compares with instructor and peer feedback across diffe…
Europe PMC · 论文发布 2026-09-21
Generative artificial intelligence in hematology is entering a new phase. The dominant question, whether large language models are accurate enough for clinical decision support, is being overtaken by a harder one, as systems shift from answ…
Europe PMC · 论文发布 2026-09-21
AlphaFold 3 (AF3) has transformed structural bioinformatics through generative diffusion modeling of biomolecular assemblies. However, intrinsically disordered regions (IDRs)—which comprise over 30% of the human proteome and mediate essenti…
Europe PMC · 论文发布 2026-09-18
Purpose Glomerulopathies are a heterogeneous group of diseases characterized by complex immunopathogenesis and wide clinical variability. A wide range of laboratory and histopathological tests is used to assess glomerular diseases. However,…
Europe PMC · 论文发布 2026-09-17
Toxicology has traditionally relied on in vivo animal studies and in vitro assays to assess the safety of drugs, chemicals and environmental contaminants. These approaches are constrained by cost, duration, ethical concerns and difficulties…
Europe PMC · 论文发布 2026-09-18
The surprise question (SQ) is an intuition-based tool for identifying patients who may benefit from palliative care, but its short-term prognostic performance in critical illness remains uncertain. Large language models may offer standardiz…
Europe PMC · 论文发布 2026-09-16
Purpose Artificial intelligence (AI) is increasingly integrated into modern otolaryngology practice and has emerged as one of the most rapidly evolving technologies in contemporary medicine. Recent advances in machine learning, deep learnin…
Europe PMC · 论文发布 2026-09-17
Bisphosphonates remain the pharmacological standard of care for osteoporosis; however, their clinical efficacy is limited by significant diagnostic gaps, heterogeneous therapeutic responses, and persistent concerns regarding long-term safet…
Europe PMC · 论文发布 2026-09-17
Purpose Cystoscopic assessment is central to bladder cancer diagnosis, yet visual interpretation remains variable. Existing artificial intelligence approaches often depend on data-intensive models that are often difficult to deploy in routi…
Europe PMC · 论文发布 2026-09-16
The vertical-valence metaphor refers to the association between emotional valence and vertical space, whereby positive and negative emotions are linked to upward and downward directions, respectively. While this mapping has been robustly ob…
Europe PMC · 论文发布 2026-09-15
Large language models (LLMs) are increasingly benchmarked against professional examination questions and interpreted as indicators of educational competence. A recent study comparing four LLMs on publicly available anatomy multiple-choice q…
Europe PMC · 论文发布 2026-09-15
Clinical discussion of artificial intelligence safety has concentrated on accuracy, bias, and hallucination, each of which describes a model failing at its assigned task. Prompt injection describes the opposite condition: a model performing…
Europe PMC · 论文发布 2026-09-15
Emerging infectious diseases (EIDs) pose a critical threat to global biosecurity. Integrating bio/chemical information and artificial intelligence would bring new strategies for antimicrobial drug discovery. Herein, the Human Pathogenic Mic…
Europe PMC · 论文发布 2026-09-14
Single-cell analysis has become an essential approach for understanding cellular heterogeneity and its implications in biological function, disease progression and therapeutic response. Microwell platforms provide a versatile approach for s…
Europe PMC · 论文发布 2026-09-09
Artificial Intelligence (AI) chatbots are becoming an efficient option to understand medical data and also help with clinical reasoning. There has been a recent progression in research of large language models and their ability to be used i…
Europe PMC · 论文发布 2026-09-09
Background Artificial intelligence (AI) and complementary digital health technologies are increasingly being applied to improve prevention, diagnosis and surveillance in travel medicine. This narrative review evaluates current applications …
Europe PMC · 论文发布 2026-09-11
To evaluate whether large language models (LLMs) can reliably reproduce a residency program's rank order list (ROL) from pre-interview application data alone versus with human interviews included, and to determine whether automated ranking …
Europe PMC · 论文发布 2026-09-08
Purpose Spine Deformity is the official journal of the Scoliosis Research Society (SRS) and the leading publication dedicated to scoliosis, deformity, and surgical correction. We applied BERTopic, a transformer-based machine learning topic-…
Europe PMC · 论文发布 2026-09-10
BackgroundLarge language model (LLM)-based generative artificial intelligence (AI) tools have rapidly entered clinical practice. In oncology pharmacy, a specialty marked by high technical complexity, strict regulatory constraints, and an ex…
Europe PMC · 论文发布 2026-09-07
Artificial Intelligence (AI) frameworks for automating scientific research have shown strong performance on benchmarks, but their utility for real-world industrial research remains insufficiently characterized. Extending the analysis presen…
Allen Institute · 论文发布 2026-09-03
Allen Institute、Fred Hutch Cancer Center 与华盛顿大学启动 AI BioDesign 项目，计划把生成式 AI、合成生物学与湿实验验证连接起来，设计新的蛋白、基因与生物系统，并通过实验反馈持续改进模型。
Owkin / Reuters · 论文发布 2026-09-02
Owkin 与勃林格殷格翰达成许可合作，后者将使用 K Pro AI Scientist 及肿瘤和免疫领域的多模态患者数据，用于靶点研究和药物发现。合作建立在双方 2025 年试点项目基础上。
Cell Death & Disease · 论文发布 2026-09-02
研究关注紫杉醇处理后逃逸凋亡的癌细胞状态，并将 ZEB1 与这些存活细胞的铁死亡敏感性联系起来，为理解化疗后的残存细胞状态提供了新的机制线索。
Nature Medicine · 论文发布 2026-09-01
在超过 1,500 名 II–III 期三阴性乳腺癌患者中，阿替利珠单抗联合新辅助化疗未达到事件无生存期主要终点。预设和探索性分析提示，淋巴结受累以及 basal-like immune-activated 等免疫相关亚型可能存在差异化获益。
Nature Medicine · 论文发布 2026-08-01
COMPASS 以 10,184 个肿瘤样本进行泛癌预训练，将 15,672 个蛋白编码基因映射到 44 个具有生物学意义的免疫概念，并在多个独立临床队列中预测免疫检查点抑制剂疗效。
Nature Biotechnology · 论文发布 2026-06-16
Isomorphic Labs 完成 21 亿美元 B 轮融资，计划扩大其 AI 药物设计引擎。Nature Biotechnology 报道称，其新一代 Drug Design Engine 在结构预测、结合亲和力与配体口袋识别等任务上强调相较 AlphaFold 3 的进一步提升。